FIGURE

Fig. 5

ID

ZDB-FIG-240223-35

Publication

Guillemyn et al., 2023 - Syntaxin 18 Defects in Human and Zebrafish Unravel Key Roles in Early Cartilage and Bone Development

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Fig. 5

Five‐dpf‐old uppercut18 zebrafish are associated with altered transcriptional levels of SNARE complex members, protein interacting components, and components of the secretory pathway. (A) Transcriptional levels of stx18 are unaltered in uppercut18, but SNARE protein members including bnip1a, bnip1b, use1, sec22ba, and sec22bb are strongly upregulated, as well as the peripheral membrane protein components scfd1, zw10, and rint1. (B) Upregulated mRNA levels in uppercut18 zebrafish of all components investigated involved in early, mid, late anterograde, and retrograde secretory pathways (mia3, serpinh1, sec23a, sec24d, kdelr2a, copa, and arf1). Each data point represents the mean of 2 technical measurements from 5 biological replicates, with highlighted mean value (line). Two‐tailed unpaired t test; *p < 0.05, **p < 0.01, and ****p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Bone Miner. Res.