FIGURE

Fig. 2

ID

ZDB-FIG-240222-37

Publication

Cassidy et al., 2023 - Systematic analysis of proximal midgut- and anorectal-originating contractions in larval zebrafish using event feature detection and supervised machine learning algorithms

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Fig. 2

Experimental design for testing reserpine effect on gut motility and datasets used to train and validate multiple logistic regression models. (A) Experimental timeline. (B) Left: Example fluorescence STM and superimposed matched events detected by FIBSI (red ticks). Right: Contraction frequencies measured per ROI (ground truth). Results represent the mean ± 95% CI. Refer to Table 2 for ANOVA and post hoc test results. *p < 0.05 for reserpine versus DMSO comparisons, #p < 0.05 for untreated versus DMSO comparisons. (C) Example fluorescence STMs. Absence of pRCs (blue arrows), absence of contraction-mediated dye transit (red arrows), and increased occurrence of non-propagating contractions (green arrows, green box at first arrow) labeled in STMs of reserpine-treated larvae. (D) Random sorting of larvae by group into training (60%) and validation (40%) datasets. (E) Outputs of FIBSI for each event in the training dataset used as prediction variables for multiple logistic regression models.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Neurogastroenterol. Motil.