FIGURE

Fig. 1

ID

ZDB-FIG-240219-31

Publication

Spratt et al., 2023 - Multivalent insulin receptor activation using insulin-DNA origami nanostructures

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Fig. 1

IRs are organized in nanoclusters at the cell membrane.

a, Schematic of DNA-PAINT used to image IRs (blue) using antibodies (red) targeting the intracellular kinase domain in adipocyte cultures. b, Cluster outlines derived from DNA-PAINT of IRs at the cell membrane of adipocytes treated with PBS (control) or with 10 nM of insulin for 10 min. The insets show the magnified regions highlighting the identified clusters. Scale bars, 1 µm (blue); 200 nm (red, inset). c, Characterization of IR clusters in control and insulin-treated adipocytes. Data are presented as mean ± standard deviation (s.d.), n = 10 cells per condition. The P values are determined by a two-tailed Mann–Whitney test.

Source data

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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