FIGURE 4

The comparison of behavioral activity, production of pro‐inflammatory factors, and response to SAHA treatment in different transgenic zebrafish. (A) The total distance of the P282S, F343L, and I107T transgenic zebrafish larvae traveled with 2.5 μM SAHA treatment. **p < 0.01 by one‐way ANOVA and subsequent Tukey's multiple comparisons (n = 20 in each group). (B) The response of the P282S, F343L, and I107T transgenic zebrafish larvae with 15 mM PTZ exposure. *p < 0.05, **p < 0.01 by one‐way ANOVA and subsequent Tukey's multiple comparisons (n = 20 in each group). The total distance of WT zebrafish traveled with PTZ exposure was set as “1”. (C) The production of IL‐1β in the P282S, F343L, and I107T transgenic zebrafish larvae at 5 dpf. *p < 0.05, **p < 0.01 by one‐way ANOVA and subsequent Tukey's multiple comparisons (n = 6 in each group and one sample = 10 pooled larvae). (D) The production of IL‐6 in the P282S, F343L, and I107T transgenic zebrafish larvae at 5 dpf. *p < 0.05, **p < 0.01 by one‐way ANOVA and subsequent Tukey's multiple comparisons (n = 6 in each group and one sample = 10 pooled larvae). (E) The production of TNF‐α in the P282S, F343L, and I107T transgenic zebrafish larvae at 5 dpf. **p < 0.01 by one‐way ANOVA and subsequent Tukey's multiple comparisons (n = 6 in each group and one sample = 10 pooled larvae).