FIGURE

Fig. 2

ID

ZDB-FIG-240131-7

Publication

Asakawa et al., 2023 - Dysregulated TDP-43 proteostasis perturbs excitability of spinal motor neurons during brainstem-mediated fictive locomotion in zebrafish

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Fig. 2

Calcium imaging of the CaPs overexpressing mRFP1-TDP-43z. (a) Lateral view of the spinal cord of Tg[SAIG213A]; Tg[UAS:GCaMP7a]; Tg[UAS:mRFP1-TDP-43z] fish at 48 hpf. Among the three CaPs shown, cell #1 (arrow) displayed the nuclear mRFP1-TDP-43z signal, whereas cell #2 and cell #3 did not. (b) ?F/F of the three CaPs before and after tactile stimulation of the head. (c, d) Comparison of maximum ?F/F values between CaPs with or without nuclear mRFP1-TDP-43z signal (Nuc RFP-T43) using non-paired (c) and paired t-tests (d). Results were obtained from 38 trials of 14 CaPs with nuclear mRFP1-TDP-43z and 10 CaPs without nuclear mRFP1-TDP-43z in three animals. The scale bar indicates 20 ?m

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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