FIGURE

Fig. 8

ID

ZDB-FIG-240124-37

Publication

Rodr�guez-Ruiz et al., 2023 - ZAKα/P38 kinase signaling pathway regulates hematopoiesis by activating the NLRP1 inflammasome

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Fig. 8

NLRP1 is activated by phosphorylation of the linker domain after activation of ZAK? A?E Number of neutrophils (A?D), and caspase?1 activity (E) in 2 dpf larvae obtained by injection of one?cell stage embryos with human NLRP1 (wild type?WT, S107A and S107D) and treated from 1 to 2 dpf by bath immersion with 1 ?M nilotinib (D, E). Representative images of neutrophils (arrows) are also shown in (C). Each dot represents one individual and the mean � SEM for each group is also shown. Data are shown as the means � SEM of two technical replicates in (E). P values were calculated by one?way ANOVA and Tukey's multiple range test. n.s., non?significant; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ EMBO Mol. Med.