ZFIN Image: Rodr�guez-Ruiz et al., 2023, Fig. 8

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Figure Caption

Fig. 8 NLRP1 is activated by phosphorylation of the linker domain after activation of ZAK? A?E Number of neutrophils (A?D), and caspase?1 activity (E) in 2 dpf larvae obtained by injection of one?cell stage embryos with human NLRP1 (wild type?WT, S107A and S107D) and treated from 1 to 2 dpf by bath immersion with 1 ?M nilotinib (D, E). Representative images of neutrophils (arrows) are also shown in (C). Each dot represents one individual and the mean � SEM for each group is also shown. Data are shown as the means � SEM of two technical replicates in (E). P values were calculated by one?way ANOVA and Tukey's multiple range test. n.s., non?significant; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.

Acknowledgments

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