FIGURE

Figure 6

ID

ZDB-FIG-231220-57

Publication

Lamiré et al., 2023 - Functional and pharmacological analyses of visual habituation learning in larval zebrafish

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Figure 6

Picrotoxinin and melatonin alter the proportions of functionally identified neurons. (A) Percent habituation for larvae during Ca2+ imaging, calculated as %Habituation=100×(1−P(Resp31→60)0.5×(P(Resp1→30)+P(Resp31→60))) (B) Heatmap of response profiles of ROIs categorized into the 12 functional clusters from larvae treated with DMSO (vehicle control, n = 428,720 total ROIs in 14 larvae), Picrotoxinin (PTX, 10 uM, n = 271,037 total ROIs in 9 larvae), or melatonin (1 uM, n = 350,516 total ROIs in 11 larvae). (C) Proportion of neurons belonging to each functional cluster across treatment groups. Distributions for violin plots are bootstrapped from 5000 replicates. (D) Same data as (C), only showing the data for PTX vs DMSO vehicle control, reordered to reflect the cluster Adaptation Profiles grouped by cluster Response Shape.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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