FIGURE

Figure 5

ID

ZDB-FIG-231218-17

Publication

Liao et al., 2023 - Deletion of prolyl hydroxylase domain-containing enzyme 3 (phd3) in zebrafish facilitates hypoxia tolerance

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Figure 5

Disruption of phd3 in zebrafish facilitates hypoxia tolerance.A, photographs of phd3-null zebrafish larvae and their wildtype siblings (phd3^−/− or phd3^+/+) (3 dpf) under normoxia (21% O₂) or hypoxia (2% O₂) for 15 h. Red arrows indicate dead zebrafish. B, survival curve of phd3-null zebrafish larvae and their wildtype siblings (phd3^−/− or phd3^+/+) (3 dpf) under hypoxia (2% O₂). C, photographs of phd3-null adult zebrafish and their wild-type siblings (phd3^−/− or phd3^+/+) (4 mpf) under hypoxia (5% O₂) for 0 h, 2 h, and 4 h. Red arrows indicate dead zebrafish. D, survival curve of phd3-null adult zebrafish and their wildtype siblings (phd3^−/− or phd3^+/+) (4 mpf) under hypoxia (5% O₂). ns, not significant; ∗p < 0.05, ∗∗∗∗p < 0.0001, using log-rank test analysis; data are representative of three independent experiments.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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