FIGURE

Fig. 6

ID

ZDB-FIG-231215-141

Publication

Britto et al., 2022 - Plexind1 negatively regulates zebrafish lymphatic development

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Fig. 6

Semaphorin 3 ligands regulate trunk lymphatic guidance. (A-F) Confocal images of the head (A-C) or trunk (D-F) vasculature showing the blood (green) and lyve1b-expressing vessels (white) in 6 dpf lyve1b:DsRed; fli1a:EGFP wild type (A,D) and sema3aasa10241 (B,E) or sema3csa15161 (C,F) mutants. Yellow arrowheads indicate misaligned ISLVs. (G) Quantitation of misaligned ISLVs at 6 dpf. (H) Quantitation of aberrant facial lymphatics at 6 dpf. (I) Quantitation of facial LEC number at 6 dpf. P>0.05 (not significant), **P<0.01 (by Mann–Whitney test); data are mean±s.d. Scale bar: 50 µm. ISLV, intersegmental lymphatic vessel. Numbers in graphs represent numbers of larvae.

Expression Data

Gene:	EGFP
Fish:	sema3aa^{sa10241/sa10241}; nz101Tg/nz101Tg; y1Tg/y1Tg sema3c^{sa15161/sa15161}; nz101Tg/nz101Tg; y1Tg/y1Tg
Anatomical Terms:	facial lymphatic network lymphatic endothelial cluster trunk lymphatic system
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sema3aa^{sa10241/sa10241}; nz101Tg/nz101Tg; y1Tg/y1Tg sema3c^{sa15161/sa15161}; nz101Tg/nz101Tg; y1Tg/y1Tg
Observed In:	trunk intersegmental vessel trunk lymph vasculature trunk lymphatic system trunk vasculature lymph vessel morphogenesis
Stage:	Day 6

Phenotype Detail

Acknowledgments

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