FIGURE

Fig. 2

ID

ZDB-FIG-231215-137

Publication

Britto et al., 2022 - Plexind1 negatively regulates zebrafish lymphatic development

Other Figures

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Fig. 2

plxnd1 is required for the alignment of developing ISLVs to blood vessels. (A-H) Still images from time-lapse movies of ISLV growth between 60 and 70 hpf in lyve1b:DsRed; kdrl:EGFP wild type (A-D) and plxnd1nz75 (E-H) larvae showing blood vessels (green) lyve1b-expressing vessels (white) from Movies 1 and 2, respectively. Yellow arrowheads indicate the distal tip of each ISLV. (I,J) Traces of ISLV growth paths for wild type (I) and plxnd1 (J) (n=4). ISLVs were traced dorsally from when they left the horizontal myoseptum. (K) Quantitation of the percentage of time the ISLVs are aligned with a blood vessel (n=4). (L) Quantitation of the number of ISLV branching events (n=4). (M) Quantitation of the ISLV meandering index (n=4). *P<0.05 (Mann–Whitney test); data are mean±s.d. Scale bar: 50 µm. ISLV, intersegmental lymphatic vessel.

Expression Data

Genes:	DsRed EGFP
Fish:	plxnd1^nz75/nz75; nz101Tg/nz101Tg; s843Tg/s843Tg
Anatomical Terms:	intersegmental vessel trunk lymphatic system
Stage:	Pec-fin

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	plxnd1^nz75/nz75; nz101Tg/nz101Tg; s843Tg/s843Tg
Observed In:	intersegmental vessel trunk lymphatic system trunk vasculature lymph vessel morphogenesis
Stage:	Pec-fin

Phenotype Detail

Acknowledgments

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