FIGURE

Fig. 1

ID

ZDB-FIG-231121-82

Publication

Trigila et al., 2023 - Accelerated evolution analysis uncovers PKNOX2 as a key transcription factor in the mammalian cochlea

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Fig. 1

Comparative functional characterization of PKNOX2 accelerated elements using transgenic zebrafish. (A) PKNOX2 locus in chromosome 11 of the human genome showing the location of ANCEs. (B–I and K–S) Fluorescent microphotographs showing the eGFP expression pattern driven by the accelerated or conserved ortholog sequence of each PKNOX2-ANCEs. Fluorescent microphotographs of BAR1156 mouse (B) and bat (C); BAR1157 mouse (D) and bat (E); BAR1158 mouse (F) and bat (G); BAR1160 mouse (H) and bat (I); TSAR.3236 mouse (K) and chicken (L); 2xHAR.32 mouse (M) and human (N); TSAR.0878 mouse (O) and chicken (P); TSAR.2216 mouse (Q) and chicken (S) transgenic zebrafish at 24, 48, and 72 hours postfertilization (hpf). Only one representative transgenic line for each sequence is shown. All transgenic lines for each sequence are shown in supplementary figures S2–S7, Supplementary material online. Bright-field (J) and fluorescent images (S) of wild-type zebrafish are also shown. Note that the yolk sac (yolk) is autofluorescent. Scale bar: 0.5 mm. nm, neuromasts of the lateral line; oc, otic capsule.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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