FIGURE

Fig. 7.

ID

ZDB-FIG-231118-24

Publication

Li et al., 2023 - The RNA-binding protein CSDE1 promotes hematopoietic stem and progenitor cell generation via translational control of Wnt signaling

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Fig. 7.

Schematic showing that Csde1 modulates HSPC development via translational control of ctnnb1 mRNA. Csde1 binds to ctnnb1 mRNA to regulate translation, further enhancing β-catenin protein level and Wnt signal transduction. In the absence of Csde1, the β-catenin protein level is reduced, which results in the downregulation of Wnt signaling, further leading to definitive hematopoiesis defects.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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