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Fig. 7.

ID: ZDB-IMAGE-231118-3
Source: Figures for Li et al., 2023

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Figure Caption

Fig. 7.

Schematic showing that Csde1 modulates HSPC development via translational control of ctnnb1 mRNA. Csde1 binds to ctnnb1 mRNA to regulate translation, further enhancing β-catenin protein level and Wnt signal transduction. In the absence of Csde1, the β-catenin protein level is reduced, which results in the downregulation of Wnt signaling, further leading to definitive hematopoiesis defects.

Acknowledgments

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