FIGURE

Fig. 5

ID

ZDB-FIG-231102-58

Publication

Sun et al., 2023 - Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish

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Fig. 5

RT-qPCR analysis after 72 hpe exposure of PFOA and alternatives to zebrafish. (a) mRNA expression levels of representative target genes downstream of PPAR?; (b) mRNA expression levels of representative target genes downstream of SREBP; (c) mRNA expression levels of sterol transport-related factors; (d) represents the correlation analysis between RNA-seq gene expression level and RT-qPCR, and the adjusted R2 was Gen-X 0.86, PFOA 0.87, HFPO-TA 0.85. n = 5, 30 zebrafish per group; * P < 0.05 compared with control group; data are expressed as mean ± SE.

Expression Data

Genes:	abcg1 acsl5 angptl4 cd36 cpt1ab fabp1b.1 fads2 hmgcra npc1l1 yjefn3
Fish:	AB
Conditions:	chemical treatment by environment: 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid chemical treatment by environment: hexafluoropropylene oxide trimer acid chemical treatment by environment: perfluorooctanoic acid
Anatomical Term:	whole organism
Stage Range:	Protruding-mouth to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Conditions:	chemical treatment by environment: 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid chemical treatment by environment: hexafluoropropylene oxide trimer acid chemical treatment by environment: perfluorooctanoic acid
Observed In:	peroxisome proliferator activated receptor signaling pathway SREBP signaling pathway sterol transport whole organism
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

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