FIGURE

Figure 3

ID

ZDB-FIG-230828-39

Publication

Nieoczym et al., 2023 - In Silico Analysis, Anticonvulsant Activity, and Toxicity Evaluation of Schisandrin B in Zebrafish Larvae and Mice

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Figure 3

The effect of schisandrin B on epileptiform-like activity in the optic tectum of larval zebrafish treated with PTZ. Six-day-old fish were incubated with schisandrin B (3 µM) for 24 h and subsequently exposed to PTZ (20 mM). After a 5 min delay, LFP recordings from the larval optic tectum were obtained. Data are shown as: number of events (nr/20 min) (A); mean duration of events (s/20 min) (B); and representative LFP recordings (C). Data were analyzed using one-way ANOVA followed by Tukey’s post hoc test. Data are depicted as individual measurements (as symbols) and mean values. The experimental groups consisted of the following number of zebrafish larvae: vehicle + vehicle − 9, vehicle + PTZ − 15, schisandrin B + vehicle − 5, and schisandrin B + PTZ − 13. *** p < 0.001 vs. vehicle + vehicle; ^{^^^} p < 0.001, ^{^^}p < 0.01 vs. vehicle + PTZ. PTZ, pentylenetetrazole.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.