Figure 3

Figure 3

The effect of schisandrin B on epileptiform-like activity in the optic tectum of larval zebrafish treated with PTZ. Six-day-old fish were incubated with schisandrin B (3 µM) for 24 h and subsequently exposed to PTZ (20 mM). After a 5 min delay, LFP recordings from the larval optic tectum were obtained. Data are shown as: number of events (nr/20 min) (A); mean duration of events (s/20 min) (B); and representative LFP recordings (C). Data were analyzed using one-way ANOVA followed by Tukey’s post hoc test. Data are depicted as individual measurements (as symbols) and mean values. The experimental groups consisted of the following number of zebrafish larvae: vehicle + vehicle − 9, vehicle + PTZ − 15, schisandrin B + vehicle − 5, and schisandrin B + PTZ − 13. *** p < 0.001 vs. vehicle + vehicle; ^{^^^} p < 0.001, ^{^^}p < 0.01 vs. vehicle + PTZ. PTZ, pentylenetetrazole.