FIGURE
Fig. 1
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- ZDB-FIG-230818-75
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- Tang et al., 2023 - Serotonin/5-HT7 receptor provides an adaptive signal to enhance pigmentation response to environmental stressors through cAMP-PKA-MAPK, Rab27a/RhoA, and PI3K/AKT signaling pathways
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Fig. 1
Effects of 5-HT7R agonist (LP-12) on CUMS-induced pigment loss in mice. (A) Experimental procedure diagram about CUMS stress and LP-12 treatment on mice. Mice are pretreated with stress from Day 1 to Day 9, then carried out LP-12 administration for 12 days. (B) 5-HT7R agonist (LP-12) could increase pigment accumulation in mice compared with CUMS group (n = 10). (C) The grayscale ratio of mice was performed at 10 or 12 days by Image J. (D) Skin tissues were serially sectioned and stained with HE assays. The HFs of mice treated with LP-12 had a significant pigmentary response compared with other groups. (E) Skin tissues were lysed and then carried out by western blot. LP-12 group could increase the expressions of 5-HT7R, Mitf, and Tyr in the stressed skin. Representative images from 3 mice are shown.
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Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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