FIGURE

Fig. 6

ID

ZDB-FIG-230810-23

Publication

Bai et al., 2023 - Structure-based developmental toxicity and ASD-phenotypes of bisphenol A analogues in embryonic zebrafish

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Fig. 6

Fig. 6. BPA, BPF, and BPS upregulate K⁺ ion channel related genes. Zebrafish embryos exposed to 0.1 %DMSO (vehicle control), BPA (2 μM), BPF (3 μM), BPS (1 μM), and VPA (5 μM; positive control) from 8 to 120 hpf were collected at 120 hpf for gene expression analysis. Gene expression fold change (Log₂) for larvae exposed to VPA (A), BPA (B), BPF (C), and BPS (D). Genes related to K⁺ channel: K⁺ channel tetramerization domain containing 4 (kctd4), kctd12, kctd13, K⁺ voltage-gated channel shaker-related subfamily, beta member 1 a(kcnab1a), K⁺ voltage-gated channel, subfamily H (eag-related), member 4a (kcnh4a), K⁺ inwardly-rectifying channel, subfamily J, member 6 (kchj6). Genes related to calcium ion channel: ryanodine receptor 1a (ryr1a), ryr1b, ryr2, ryr3, troponin C type 1a (tnnc-1), and tnnc-2. Sodium ion channel gene: voltage-gated, type IV, beta b (scn4bb). Acetylcholine receptor gene: cholinergic receptor nicotinic alpha 1 subunit (chrna1). Values are plotted as the mean ± SEM (N = 3, pooled sample from 20 larvae per replicate), and the asterisk (*) indicates a significant difference from the vehicle control (0.1 % DMSO) at P < 0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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