FIGURE

Fig. 5

ID

ZDB-FIG-230805-5

Publication

Kent et al., 2023 - Zebrafish her3 knockout impacts developmental and cancer-related gene signatures

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Fig. 5

Fig. 5. her3 null mutant lines are significantly smaller than wildtype WIK at 24hpf. (A–D) Brightfield images of 24hpf wildtype WIK (A), 24hpf her3^nch1 (B), 24hpf her3^nch2 (C), and 24hpf her3^nch3 (D) embryos. Images were taken on a Leica M205FA fluorescent stereoscope. Scale bar is 500 μm. (E) The standard length of each embryo was measured and graphed here. WIK: n = 28. her3^nch1: n = 25. her3^nch2: n = 25. her3^nch3: n = 13. For each comparison to WIK, p < 1.00 × 10⁻⁴ using a one-way ANOVA with Dunnett test. (F–G) Brightfield images of 72hpf wildtype WIK (F) and 72hpf her3^nch1 (G) embryos. (H) The standard length of each 72hpf embryo was also measured and graphed here. n = 10 for both WIK and her3^nch1. Each point is an individual fish. An unpaired Welch's t-test indicated this comparison was not statistically significant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	her3^nch1/nch1 (WIK) her3^nch2/nch2 (WIK) her3^nch3/nch3 (WIK)
Observed In:	whole organism
Stage Range:	Prim-5 to Protruding-mouth

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 496, Kent, M.R., Calderon, D., Silvius, K.M., Kucinski, J.P., LaVigne, C.A., Cannon, M.V., Kendall, G.C., Zebrafish her3 knockout impacts developmental and cancer-related gene signatures, 1141-14, Copyright (2023) with permission from Elsevier. Full text @ Dev. Biol.