FIGURE

Figure 8

ID

ZDB-FIG-230729-10

Publication

Zhang et al., 2023 - A Role for Microsomal Glutathione Transferase 1 in Melanin Biosynthesis and Melanoma Progression

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Figure 8

Knockdown of Mgst1 suppressed B16 melanoma tumor progression in C57BL/6 mice. C57BL/6 mice were inoculated (subcutaneously, sc) with 0.3 × 10⁶ murine melanoma B16 NT and Mgst1 KD cells on day 0, and starting on day 7, body weights and tumor sizes were measured every day. A, growth curves for B16 melanoma (n = 9/group). B, representative whole-body in vivo bioluminescent images of mice from each group at the end of study. C, digital photograph and (D) weights of excised B16 tumors at the end of study (n = 9/group). E, changes in the body weights of B16 tumor-bearing mice (n = 9/group). F, chemokine expression analyzed by R&D Chemokine Array. Tumor lysates were analyzed for protein content by bicinchoninic acid protein assay (n = 3/group). ∗, ∗∗, and ∗∗∗ indicate p < 0.05, p < 0.005, and p < 0.0005, respectively. KD, knockdown; MGST, microsomal glutathione transferase; NT, nontargeting.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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