FIGURE

Fig. 2

ID

ZDB-FIG-230712-9

Publication

Siddiqui et al., 2023 - Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer's disease

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Fig. 2

NGFR promotes proliferation of DG astrocytes and neurogenesis in wild type and APP/PS1dE9 model of AD.

Immunostaining for GFAP, BrdU and mCherry with DAPI counterstain in Lv13- (a) and Lv16- (b) SGZ of wild type mice. a1, b1. BrdU/mCherry channels of a and b. c Quantification graph for mCherry-BrdU-GFAP triple positive cells. d, e Immunostaining for Dcx, BrdU and mCherry with DAPI counterstain in Lv13- (a) and Lv16-transduced (b) SGZ. d1, e1. BrdU/mCherry channels of d and e. f Quantification graph for mCherry-BrdU-Dcx triple positive cells of wild type mice. Immunostaining for GFAP, BrdU and mCherry with DAPI counterstain in Lv13- (g) and Lv16-transduced (h) SGZ of APP/PS1dE9 mice. g1, h1. BrdU/mCherry channels of g and h. i Quantification graph for mCherry-BrdU-GFAP triple positive cells. Immunostaining for Dcx, BrdU and mCherry with DAPI counterstain in Lv13- (j) and Lv16-transduced (k) SGZ of APP/PS1dE9 mice. j1, k1. BrdU/mCherry channels of j and k. l Quantification graph for mCherry-BrdU-Dcx triple positive cells. m Quantification of BrdU/mCherry double positive cells in wild type mice (control and Ngfr+). n Quantification of BrdU/mCherry double positive cells in APP/PS1dE9 mice (control and Ngfr+). Scale bars equal 50 µm. Error bars represent the standard error of the means, with each point representing one section. 3 mice were used.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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