FIGURE

Fig. 6

ID

ZDB-FIG-230712-13

Publication

Siddiqui et al., 2023 - Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer's disease

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

LCN2 is upregulated in human brains with AD.

Immunohistochemical stainings for LCN2 and GFAP on hippocampal brain sections of healthy control (a, b) and CERAD score C AD patient (c, d). Black-white insets (a1–d2) indicate individual fluorescent channels. LCN2 (top) and GFAP (bottom). e Quantification of LCN2-positive GFAP cells normalized to total GFAP cells. In total n = 7 human brains, n = 21 images analyzed. ***p < 0.001. f Immunostaining for GFAP on primary human astrocytes in 3D hydrogels: control and LCN2-treated. g Quantification of the volume of GFAP normalized to total number of GFAP cells. LCN2-treatment reduces the volume of astroglia, indicative or reactive states. Scale bars equal 50 μm. h GFAP and MAP2 immunostaining on control and LCN2-treated 3D hydrogel cultures of human primary fetal astroglia. i Quantification of normalized GFAP and MAP2-positive cells after the culture period. Scale bars equal 25 μm. Error bars represent standard error of the means.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ NPJ Regen Med