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Fig. 1

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ZDB-FIG-230707-100

Publication

Kim et al., 2023 - Comparison of the effects of empagliflozin and sotagliflozin on a zebrafish model of diabetic heart failure with reduced ejection fraction

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Fig. 1

Comparison of survival rates in DM-HFrEF model zebrafish treated with empagliflozin or sotagliflozin.

Survival analysis of DM-HFrEF zebrafish larvae after treatment with 0.2, 1, 5 and 25 μM empagliflozin or sotagliflozin. a, c Kaplan‒Meier survival curves (n = 120 larvae per group). b, d Ccross-sectional comparisons at the time points of 8 and 9 dpf and are presented as the mean ± standard deviation; each dot represents the value from one experiment (n = 3–6 experiments per group). The non-DM and DM groups were tested under the same conditions on the same day, and the graph is shown in Fig. 1 and Supplementary Fig. 2. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 vs. the indicated group.

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