FIGURE

Fig. 3

ID

ZDB-FIG-230612-9

Publication

Hodorovich et al., 2023 - Morphological and sensorimotor phenotypes in a zebrafish CHARGE syndrome model are domain-dependent

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Fig. 3

LLC deficit is independent of otolith morphology in chd7 chromodomain mutants. (A) Acoustic startle responses, average short‐latency c‐bend (SLC) frequency comparing chd7 ^ncu101/+ and chd7 ^{ncu101/ncu101} with or without otolith defects (chd7 ^+/+ n = 11, chd7 ^ncu101/+ w/o otolith defect n = 22, chd7 ^ncu101/+ with otolith defect n = 17, chd7 ^{ncu101/ncu101} w/o otolith defect n = 8, chd7 ^{ncu101/ncu101} with otolith defect n = 11) (mean ± SEM). (B) Short‐latency c‐bend sensitivity index, calculated by the area under the SLC frequency curves for individual larvae (mean ± SD, Ordinary one‐way ANOVA with Tukey's multiple comparison). (C) Long‐latency c‐bend (LLC) frequency as acoustic stimulus intensity increases (mean ± SEM). (D) Long‐latency c‐bend sensitivity index calculated by the area under the LLC frequency curves for individual larvae (mean ± SD, Ordinary one‐way ANOVA with Tukey's multiple comparison, **p < 0.01, ****p < 0.0001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	chd7^{ncu101/ncu101} (TL)
Condition:	acoustic radiation
Observed In:	otolith startle response
Stage:	Day 5

Phenotype Detail

Acknowledgments

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