FIGURE

Figure 4

ID

ZDB-FIG-230515-44

Publication

Bulk et al., 2023 - Holoprosencephaly with a Special Form of Anophthalmia Result from Experimental Induction of bmp4, Oversaturating BMP Antagonists in Zebrafish

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Figure 4

ISH at 11 hpf after bmp4-induction at 8.5 hpf. (A): summary of experimental procedure: embryos were heat-shocked at 8.5 hpf and analyzed at 11 hpf; left columns wildtypes, right columns bmp4-induced;first and third column dorsal view, second and fourth column lateral view. (B–E): Expression of shha is reduced in the area of the prechordal plate (arrows) after bmp4-induction yet still present. (F–I): shhb expression is also still present after bmp4-induction but reduced in intensity (arrows). (K–N): Expression of zic2a is absent in the ANP domain (arrows) after bmp4-induction. (O–R): expression of cxcr4a in the eye field is strongly reduced after bmp4-induction. scalebars indicate 200 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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