Fig. 4

Loss of sox10 rescues the skeletal but not ectomesenchyme program in nr2f5^ci/ci mutants. (A) Possible genetic relationships linking Nr2f2 and/or Nr2f5, sox10 and the ectomesenchyme program. (B) Ectomesenchyme genes were more dramatically reduced in nr2f5^ci/ci and double nr2f2^ci/ci;nr2f5^ci/ci mutants (compare with Fig. 1D, Fig. S2). Expression is not rescued by reducing sox10 dose. (C,D) Loss of one or two copies of sox10 rescues the hyomandibular and ceratobranchial phenotypes of nr2f5^ci/ci single mutants (C) but not the more severe defects of nr2f2^ci/ci;nr2f5^ci/ci mutants (D). In C, 10/11, 4/15 and 0/13 nr2f5^ci/ci mutants that were, respectively, wild type, heterozygous or mutant for sox10 showed hyomandibular and ceratobranchial phenotypes. Scale bars: 100 µm.