FIGURE

Fig. 1.

ID

ZDB-FIG-230420-8

Publication

Liu et al., 2022 - Chemokine signaling synchronizes angioblast proliferation and differentiation during pharyngeal arch artery vasculogenesis

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Fig. 1.

Genetic depletion of cxcr4a induces PAA malformation. (A) The expression of cxcr4a at 24 (dorsal view with anterior towards the top), 36 and 48 hpf (lateral views with anterior towards the left). Black arrowheads indicate the expression of cxcr4a in the pharynx. (B,C) Colocalization of cxcr4a transcripts and ZsYellow⁺ PAA angioblasts. Tg(nkx2.5:ZsYellow) embryos were stained with anti-ZsYellow antibody (red) and hybridized with cxcr4a probes (green) by fluorescent in situ hybridization. (D,E) Confocal images depicting blood flows in wild-type (WT) and cxcr4a-deficient embryos. PAAs 3-6 are marked with corresponding numbers. The ratios of affected embryos are indicated in the lower right corner. (F) The expression of tie1 and flk in wild type (WT) and cxcr4a^−/− mutants. Scale bars: 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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