FIGURE

Fig. 2

ID

ZDB-FIG-230115-54

Publication

Leventea et al., 2021 - Ciliopathy genes are required for apical secretion of Cochlin, an otolith crystallization factor

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Otolith crystallization defects in cep290 mutant homozygotes. (A) Example scanning electron microscopy images of wild-type and cep290^sa1383 otoliths at 18 mo (Scale bar, 300 μm). Enlargements in Bottom panels (Scale bar, 150 μm) (n = 3). (B) Side views of otic vesicles in live wild-type and cep290^sa1383 homozygous embryos at 36 hpf. In the posterior ear, in the mutant example, two closely apposed otoliths are seen, where one is expected. Anterior is Left, dorsal Up, arrowheads indicate otoliths. (C) Frequency of otolith defects at 36 hpf. P < 0.001, χ² test. (D) Typical example of cobalt nitrate staining of utricular otoliths in wild-type and cep290^sa1383 mutants (n = 20).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cep290^{sa1383/sa1383}
Observed In:	lapillus lapillus otolith mineralization otolith otolith morphogenesis
Stage Range:	Prim-25 to Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA