FIGURE

Figure 2

ID

ZDB-FIG-230115-36

Publication

Bearce et al., 2022 - Urotensin II-related peptides, Urp1 and Urp2, control zebrafish spine morphology

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Figure 2

Urp1 and Urp2 are required for proper adult spine morphology.

(A–C) Lateral views of microcomputed tomography reconstitutions of wild-type (A), urp1^∆P;urp2^∆P (B) and uts2r3^b1436 (C) mutants at 3 mpf. (D) Cobb angle measurements for individual fish in the sagittal plane for urp1^∆P;urp2^∆P and uts2r3^b1436 mutants. Circles represent angles for individual curves. (E-E’) Total Cobb angles with each circle representing an individual fish. The mean ± s.d. is shown. (G’) is the data from G parsed for sex. p-Values are given from two-tailed unpaired student’s t tests. (F) The position of curve apex is plotted and shows that most curves are in caudal vertebrae. n=9 and 8 for urp1^∆P;urp2^∆P and uts2r3^b1436 mutants, respectively.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	uts2r3^b1436/b1436 (AB) urp2^b1421/b1421; urp1^b1420/b1420 (AB)
Observed In:	female organism skeletal system development female organism vertebral column male organism skeletal system development male organism vertebral column vertebral column vertebral column posterior region vertebral column skeletal system development
Stage:	Adult

Phenotype Detail

Acknowledgments

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