FIGURE

Figure 7

ID

ZDB-FIG-230110-17

Publication

Chen et al., 2022 - A Novel Antimicrobial Peptide Sp-LECin with Broad-Spectrum Antimicrobial Activity and Anti-Pseudomonas aeruginosa Infection in Zebrafish

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Figure 7

In vitro cytotoxicity and hemolytic activity and the in vivo effectiveness of Sp-LECin. The cytotoxicity of Sp-LECin on crab hemocytes (A), human embryonic kidney cells (HEK-293T) (B), human hepatic cells (L02) (C), and mouse embryonic fibroblast (3T3) (D), were determined by the MTS-PMS assay. (E) Hemolytic activity of Sp-LECin against mouse red blood cells. Significant difference between the control group and the Sp-LECin treatment group was indicated by asterisks as * p < 0.05 and ** p < 0.01. The bars indicated the mean � standard error of mean (n = 3). (F) In vivo effectiveness of Sp-LECin in P. aeruginosa-challenged zebrafish (n = 20/group). The survival curve of each group was analyzed using the log-rank test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Condition:	bacterial treatment by injection: Pseudomonas aeruginosa
Observed In:	whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

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