FIGURE

Figure 1

ID

ZDB-FIG-230107-25

Publication

Kodani et al., 2022 - A Drosophila model of the neurological symptoms in Mpv17-related diseases

Other Figures

All Figure Page

Back to All Figure Page

Figure 1

CG11077 is an ortholog of human MPV17. (A) A phylogenetic tree was constructed with amino acid sequences of MPV17/PMP22 family proteins, human (MPL, FKSG24, PXMP22, and MPV17), S. cerevisiae SYM1, D. melanogaster (CG7970, CG14777, CG144778, CG32262, CG32263, CG1662, CG12355, and CG11077), C. elegans Mpv17-like, and Mpv17s (mouse, rat, zebrafish, and X. laevis). The sequence similarity of MPV17/PMP22 family proteins among model organisms and the human MPV17 family was analyzed. (B) Multiple alignment of amino acid sequences of Mpv17 among model organisms and human, including CG11077, was carried out with the Clustal Omega multiple sequence alignment program. Amino acids conserved among all organisms are marked by asterisks and those conserved between D. melanogaster and others are highlighted in gray. The black and white arrowheads indicate the amino acids mutated in MPV17-related hepatocerebral MDDS (R50Q) and CMT (R41Q and P98L) patients, respectively. Underlining indicates the amino acid sequences conserved between PMP22 and MPV17 (Mpv17/PMP22: IPR007248).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.