FIGURE

Figure 6

ID
ZDB-FIG-221226-110
Publication
Lo et al., 2022 - GTP-Binding Protein 1-Like (GTPBP1l) Regulates Vascular Patterning during Zebrafish Development
Other Figures
All Figure Page
Back to All Figure Page
Figure 6

Interactions among gtpbp1l, VEGF/Notch, and BMP signals. (AC) At 24 hpf, the expression level of gtpbp1l was decreased in SU5416-treated (B) and DAPT-treated embryos (C) compared to DMSO-treated control embryos. (DF) At 30 hpf, inhibition of BMP signals by DM or DMH1 treatment reduced the expression of gtpbp1l in embryos compared with that in DMSO-treated control embryos. (A’F’) Enlargements of (AF). (G) The relative expression level was quantified by the qPCR assay and showed a significantly decreased expression of gtpbp1l in SU5416-treated (0.59 ± 0.23) and DAPT-treated (0.27 ± 0.12) embryos compared to controls. (H) Quantification of the relative expression level by qPCR analysis in DM-treated (0.51 ± 0.23) and DMH1-treated (0.42 ± 0.19) embryos had the reduced expression of gtpbp1l, which is normalized to DMSO-treated controls. Values on the bottom right indicate the number of embryos exhibiting the phenotype per total number of embryos analyzed. Data are represented as means ± S.D. *** refers to p < 0.0001 and ** p < 0.001 by unpaired Student’s t-test. Scale bars are 200 µm.

Expression Data
Gene:
Fish:
Conditions:
Anatomical Terms:
Stage Range: Prim-5 to Prim-15

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Conditions:
Observed In:
Stage Range: Prim-5 to Prim-15

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Biomedicines