FIGURE

Fig. 3

ID

ZDB-FIG-221219-3

Publication

Bobone et al., 2021 - Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting Its Protein-Protein Interactions

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Fig. 3

In silico free energy calculations for different modified sequences. The free energy profile is reported as a function of the distance between the centers of mass of the N-SH2 domain and the phosphopeptide. The simulations predict a loss of affinity of P8 (blue line) with dephosphorylation of the pY (dashed blue line; P8Y0 is the unphosphorylated analogue of P8) and a gain with substitution of L at position +5 with W (red line), but not with F (violet line). The additional substitution of D at position +4 with E (orange) does not provide any further increase in affinity. Shaded areas correspond to standard deviations in the PMF profile. For peptide sequences, see Table1.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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