FIGURE

Fig 7

ID

ZDB-FIG-221218-34

Publication

McCarthy et al., 2022 - An amino-terminal fragment of apolipoprotein E4 leads to behavioral deficits, increased PHF-1 immunoreactivity, and mortality in zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig 7

The presence of nApoE4_1-151 within tail regions of zebrafish embryos.

A-C: Representative images from confocal immunofluorescence in 5 mm paraffin-embedded sections of non-treated control 48 hpf zebrafish embryos that were stained with DAPI (A), anti-His antibody (1:500) (B), and the merged image together with PHF-1 (1:250) in Panel (C). There was no detection of any nApoE4_1-151 fragments in untreated control sections as indicated by the lack of labeling in Panel B. D-F: Identical to Panels A-D with the exception that embryos were exogenously treated for 24 hours with 25 μg/ml of nApoE4_1-151. In this case punctate staining of the fragment was observed that appeared cytoplasmic. PHF-1 labeling was identified in muscle cells that exhibited abnormal morphology (arrows, Panel F). All scale bars represent 20 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One