FIGURE

Fig 5

ID

ZDB-FIG-221218-27

Publication

McCarthy et al., 2022 - An amino-terminal fragment of apolipoprotein E4 leads to behavioral deficits, increased PHF-1 immunoreactivity, and mortality in zebrafish

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Fig 5

Tau pathology present after treatment with exogenous nApoE4_1-151 fragment in 72 hpf zebrafish brain.

Representative 40X images from confocal immunofluorescence in 5 mm paraffin embedded sections of non-treated control 72 hpf zebrafish (A-D), nApoE3_1-151-treated at 25 ?g/ml (E-H), or nApoE4_1-151-treated at 25 ?g/ml (I-L). Strong PHF-1 labeling was only observed following treatment with nApoE4_1-151 (I-L). Panel K depicts a separate, representative merged image following treatment with nApoE4_1-151. In this case, at high magnification the fibrillar nature of PHF-1 labeling was apparent. All scale bars represent 50 ?m. Data are representative of three independent experiments.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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