FIGURE

Fig. 3

ID

ZDB-FIG-221210-3

Publication

Walker et al., 2021 - Agrin/Lrp4 signal constrains MuSK-dependent neuromuscular synapse development in appendicular muscle

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Fig. 3

MuSK is required for pectoral fin neuromuscular synapse development. (A) Schematic of the Agrin/Lrp4/MuSK pathway. (B) Schematic of a larval zebrafish at 120 hpf. Red boxes outline regions of the fin and trunk that are shown in C,D. (C) Abductor muscle innervation in the pectoral fin in 120 hpf larvae expressing Tg(mnx1:GFP) to label motoneurons and stained with α-Btx to label AChRs. musk heterozygous sibling pectoral fins exhibit an innervation pattern with numerous small AChR clusters (n=45/45), whereas musk mutants have an exuberant innervation pattern with diffuse AChR signal throughout muscle fibers in the fin and some focal AChR clusters (n=25/25). (D) Trunk innervation from the same animals shown in C. musk mutants form fewer and smaller neuromuscular synapses compared with sibling controls. SC, spinal cord.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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