FIGURE

Fig. 7

ID

ZDB-FIG-221109-37

Publication

Zhou et al., 2022 - Dusp6 deficiency attenuates neutrophil-mediated cardiac damage in the acute inflammatory phase of myocardial infarction

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Fig. 7

a Western blot of pERK in WT PMNs in unoperated controls and 6–72 h after MI (n = 6/group). Both blots were performed in parallel with the same samples. b, c Western blot and quantitative analysis of pERK levels in WT and Dusp6-deficient PMNs in unoperated controls and 6–72 h after MI (n = 6/group). d, e Western blot and quantitative analysis of p-p38 and pJNK in PMNs from unoperated WT and Dusp6-deficient rats (n = 6/group). f, g Western blot and quantitative analysis of pERK and p-p38 levels in unoperated WT PMNs treated with either p38 inhibitors (BIRB796 and SB203580) or MEK1/2 inhibitors (SL327 and U0126). DMSO was used as a negative control (n = 4 independent experiments). All blots within each individual panel were performed in parallel with the same samples. All quantitative data shown in this figure are presented as mean values ± SD. One-way ANOVA with Tukey’s multiple comparison test (for c and g) and Two-sided unpaired T-test (for e) were used to calculate the presented p-values. Source data of a–g are provided in a Source Data File. WT wild-type, MT Dusp6 mutant.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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