FIGURE

Figure 6

ID

ZDB-FIG-221031-195

Publication

Chun et al., 2022 - Novel Cinnamaldehyde Derivatives Inhibit Peripheral Nerve Degeneration by Targeting Schwann Cells

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Figure 6

In silico analysis for the pharmacological mechanism of 3f and the validation in hTERT02.3 cells. Bioinformatics analysis using 150 DEGs or 21 DE miRNAs regulated by CAH in non-small cell lung cancer cell lines (NSCLC: SK-MES-1 and NCI-H226 cell lines) [11] was performed. (A,D) Gene ontology (GO), (B,E) Kyoto encyclopedia of genes and genomes (KEGG), and (C,F) protein domain analyses were performed using DAVID bioinformatics resources (https://david.ncifcrf.gov/; accessed on 10 March 2022) and PFAM protein family database (https://pfam.xfam.org/; accessed on 10 March 2022). The bar graph represented the value of ‘−log (p-value)’, and the line graph showed the gene counts. (G) The mRNA levels of seven coding genes related to cell growth and oxidative stress were validated in hTERT02.3 cells with or without 3f treatment by qPCR. ** p < 0.01 and *** p < 0.001. (H) The miRNA levels of 10 miRNAs related to cell cycle were validated in hTERT02.3 cells by qPCR. * p < 0.05 and ** p < 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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