FIGURE

Fig. 6

ID

ZDB-FIG-220926-36

Publication

Xiao et al., 2022 - Down-Regulation of Double C2 Domain Alpha Promotes the Formation of Hyperplastic Nerve Fibers in Aganglionic Segments of Hirschsprung's Disease

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Fig. 6

Investigation of Doc2a down-regulation promoting hyperplastic nerve fibers in zebrafish intestinal tract. (A–D) Comparison of enteric nerve fibers (Tubulin) in different groups. (E–H) Comparison of enteric neurons (HuC/D) in different groups. Red arrow, enteric nerve fiber; yellow arrowhead, enteric neuron. (I) Diagram of zebrafish. (J) Comparison of average number of enteric neurons in zone 1 and 2. (K) Comparison of length proportion of intestinal tract with hyperplastic nerve fibers in zone 1 and 2. #, p > 0.05; ***, p < 0.001, one-way ANOVA with Bonferroni post hoc, n = 3. Abbreviations: MO, Morpholino; ret, ret proto-oncogene.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO2-doc2a WT + MO5-ret WT + MO2-doc2a + MO5-ret
Knockdown Reagents:	MO2-doc2a MO5-ret
Observed In:	intestine enteric neuron intestine neuron projection
Stage:	Day 5

Phenotype Detail

Acknowledgments

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