FIGURE

Fig. 5

ID

ZDB-FIG-220926-35

Publication

Xiao et al., 2022 - Down-Regulation of Double C2 Domain Alpha Promotes the Formation of Hyperplastic Nerve Fibers in Aganglionic Segments of Hirschsprung's Disease

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Fig. 5

Comparison of neuron polarity among different neural sphere groups. (A–C) Nerve fiber phenotypes of neural spheres in different groups. (D–F) Partial enlarged drawing of (A–C) separately. (G–I) IF (Tuj1) showed the nerve fibers and neurites of neural spheres. Red arrow, nerve fiber; yellow arrowhead, neurite. (J) Comparison of average number of nerve fiber connections. (K) Comparison of average number of neurite outgrowth per neural sphere. **, p < 0.01; ***, p < 0.001, one-way ANOVA with Bonferroni post hoc, n = 3. Knockdown, infected with Doc2a-lentivirus; negative control, Lentivirus Luciferase Reporter negative control; blank control, cultured with an equal medium. Abbreviations: IF, immunofluorescence; DAPI, 4’,6-diamidino-2-phenylindole.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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