FIGURE

Fig. 6

ID

ZDB-FIG-220919-6

Publication

Lukasz et al., 2022 - Chronic neurotransmission increases the susceptibility of lateral-line hair cells to ototoxic insults

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Fig. 6

Red-shifted oxidized MitoTimer signal is reduced in ca_v1.3a and otofb mutants.

(A–C) Hair cells in wildtype (A), cav1.3a^-/- mutant (B), and otofb^-/- mutant (C) Tg[myosin6b:mitoTimer]^w208 neuromasts at 5 dpf. (D–E) Average dot plots of the ratio of red/green MitoTimer fluorescence intensity at 3, 5, and 6 dpf in cav1.3a^-/- mutant fish (blue) (D) and otofb^-/- mutant fish (orange) (E) and respective siblings (black, gray) show that mutants exhibit reduced mitochondrial oxidation over time. Each dot in D and E represents one neuromast. A minimum of 3 animals and 10 neuromasts were examined per treatment group. Error bars: SEM. For comparisons, a two-way ANOVA with a Sidak’s correction for multiple comparisons was used in D-E. * p<0.05, *** p<0.001, **** p<0.0001. Scale bar = 5 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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