FIGURE

Fig. 7

ID

ZDB-FIG-220913-14

Publication

Fatás-Lalana et al., 2022 - Impact of Comorbidities of Patients with Psoriasis on Phototherapy Responses

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Fig. 7

Impact of Dpp4 in zebrafish models of diabetic comorbidity in psoriasis. (a–c) Representative bright field and merge (bright field and red fluorescence) images and quantitation of skin neutrophil infiltration and the number of keratinocyte aggregates (arrows) in 3 dpf larvae after dpp4 genetic inhibition using CRISPR/Cas-9 technology in the presence of 25 mM glucose (b). (c) Analysis of genome editing efficiency in larvae injected with control or dpp4 crRNA/Cas-9 complexes and quantification rate of NHEJ-mediated repair showing all INDELs (https://tide.nki.nl/). Each dot represents one individual, and the mean ± SEM for each group is also shown. p-Values were calculated using 1-way ANOVA and Tukey multiple range test. ns, not significant, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	spint1a^{hi2217Tg/hi2217Tg}; nz50Tg
Condition:	chemical treatment by environment: glucose
Observed In:	keratinocyte neutrophil
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.