FIGURE

Fig. 6

ID

ZDB-FIG-220913-13

Publication

Fatás-Lalana et al., 2022 - Impact of Comorbidities of Patients with Psoriasis on Phototherapy Responses

Other Figures

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Fig. 6

Impact of glucose in zebrafish models of diabetic comorbidity in psoriasis. (a) Scheme showing the distribution of neutrophils in wild type and Spint1a-deficient zebrafish larvae. (b–d) Representative bright field and merge (bright field and red fluorescence) images and quantitation of skin neutrophil infiltration and the number of keratinocyte aggregates (arrows) in 3 dpf larvae treated with 10 µM WZB117 for 48 h in the presence or absence of 25 mM glucose or galactose (c), or 1 mM NAD⁺ (d). Each dot represents one individual, and the mean ± SEM for each group is also shown. p-Values were calculated using 1-way ANOVA and Tukey multiple range test. ns, not significant, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	spint1a^{hi2217Tg/hi2217Tg}; nz50Tg
Conditions:	chemical treatment by environment: galactose chemical treatment by environment: glucose chemical treatment by environment: inhibitor chemical treatment by environment: galactose chemical treatment by environment: NAD chemical treatment by environment: glucose
Observed In:	keratinocyte neutrophil
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.