FIGURE

Fig. 2

ID

ZDB-FIG-220912-138

Publication

Bartoszewski et al., 2022 - A Zebrafish/Drosophila Dual System Model for Investigating Human Microcephaly

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Fig. 2

Wild type tubgcp2 mRNA pre-empts microcephaly in tubgcp2-depleted morphants at 3 dpf. (a) Percent of morphant larvae obtained with microcephaly when treated with tubgcp2 translation-inhibiting or splicing-inhibiting MO (see Supplementary Table S1 for experimental numbers and statistics). (b) Microcephaly index = head width/body length ratio = (c)/(d) for tubgcp2-depleted and tubgcp2 mRNA-rescued morphants. (c) Head width; (d) body length. Statistical multiple comparisons completed using one-way ANOVA; * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001. This includes Ŝidák’s correction for multiple comparisons.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB/TL + MO1-tubgcp2 + MO4-tp53 AB/TL + MO2-tubgcp2 + MO4-tp53
Knockdown Reagents:	MO1-tubgcp2 MO2-tubgcp2 MO4-tp53
Observed In:	head whole organism
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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