FIGURE

Fig. 2

ID

ZDB-FIG-220906-13

Publication

Toh et al., 2022 - Optogenetic control of YAP cellular localisation and function

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Fig. 2

Figure 2. Light activation of optoYAP can activate downstream YAP target genes and control cell proliferation

A. Expression levels of ANKRD1, CTGF, and CYR61 transcripts in HEK293T cells transfected with optoYAP after 48 h of activation protocol. Gene expression level was normalised to the housekeeping gene, EIF1B. Horizontal bars represent mean and 95% confidence interval from six biological replicates across two independent experiments for each condition, ***P < 10⁻³ (unpaired t-test).
B, C. Cell proliferation assay. HEK293T (B) and HFF (C) cells were transfected with optoYAP and subjected to activation protocol as described in Fig 1A or kept in the dark for 1 week. Error bars are s.d., n = 3 independent experiments for each condition, **P < 10⁻² (unpaired t-test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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