FIGURE
Fig. 6
- ID
- ZDB-FIG-220905-6
- Publication
- Neuffer et al., 2022 - AP-3 complex delta subunit gene, ap3d1, regulates melanogenesis and melanophore survival via autophagy in zebrafish (Danio rerio)
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Fig. 6
Autophagy inhibition with bafilomycin A1 negatively impacts melanophore survival in crasher (ap3d1) mutants. (a–d) Melanophore morphology of mutant fish treated with 50 nM bafilomycin A1 appears more punctate. (e) Melanophore count boxplot of crasher mutants and wild-type siblings treated with bafilomycin A1 or DMSO. Bafilomycin A1-treated mutants have 39.51% fewer melanophores (μ = 39.2, SD = 4.75) than DMSO-treated mutants (μ = 64.8, SD = 6.76). Bafilomycin A1-treated wild-type siblings have 15.74% fewer melanophores (μ = 68.0, SD = 8.70) than DMSO-treated wild-type siblings (μ = 80.7, SD = 3.39). (two-way ANOVA, phenotype F(1, 20) = 77.03, p = 2.71 x 10−8, treatment F(1, 20) = 56.74, p = 2.92 × 10−7, interaction F(1, 20) = 6.53, p = 0.02, Tukey HSD performed to determine group differences, p = <0.001 ***, p = <0.01 **, p = <0.05*). Scale bar is 500 μm.
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Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
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| Stage: | Day 5 |
Phenotype Detail
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Full text @ Pigment Cell Melanoma Res.