FIGURE

Figure 3

ID

ZDB-FIG-220827-25

Publication

Elfatih et al., 2022 - Analysis of incidental findings in Qatar genome participants reveals novel functional variants in LMNA and DSP

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Figure 3

Zebrafish DSP model cardiac blood flow pulse in Dorsal Aorta. Modeling Qatar Genome Programme human DSP cardiac variant produced altered blood flow pulse in the dorsal aorta (DA) of the zebrafish model, representative charts at 72 hours post-fertilization (hpf): (A) Video recordings of high-speed acquisition of the blood flow (60 frames per second) were processed, a selected area of the DA with circulating red blood cells was used to calculate the cardiac blood flow pulse. A representative flow profiles chart for the analysis provides a color-coded pulse over time (6 s). (B) Representative individual pulse of analyzed data (n = 12 per group).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO2-dspb + MO3-dspa
Knockdown Reagents:	MO2-dspb MO3-dspa
Observed In:	dorsal aorta blood circulation
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Hum. Mol. Genet.