FIGURE

Figure 9

ID

ZDB-FIG-220827-22

Publication

Crouzier et al., 2022 - Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines

Other Figures

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Figure 9

Analysis of mitochondrial respiration in zebrafish larvae at 2 and 5 dpf with Seahorse XF mito stress test. OCR profiles of (A–L) wfs1a^C825X at 2 dpf (A–F) and 5 dpf (G–L); and OCR profiles of (M–X) wfs1b^W493X at 2 dpf (M–R) and 5 dpf (S–X) during the assay, with (B, H) basal respiration, (C, I) ATP production, (D, J) maximal respiration, (E, K) proton leak and (F, L) non-mitochondrial respiration. Error bars represent ± SEM calculated from three replicas. The number of animals is indicated below the columns. ^*P < 0.05, ^**P < 0.01; unpaired t-test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	wfs1a^{sa11465/sa11465} (AB) wfs1b^{sa16422/sa16422} (AB)
Observed In:	whole organism ATP biosynthetic process whole organism cellular respiration
Stage Range:	Long-pec to Day 5

Phenotype Detail

Acknowledgments

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