FIGURE

Figure 5

ID

ZDB-FIG-220827-18

Publication

Crouzier et al., 2022 - Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines

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Figure 5

Molecular characterization of the retina and measure of the motor neuron length for both wfs1 mutant zebrafish lines. Retina measurements in wfs1 mutants with (A) quantification of the number of ganglion cells, (B) the thickness of the associated layer and (C) photoreceptors cells as red and green cones labeled with Zpr-1 antibody and (D) rods with anti-Rho4d2 antibody. Quantification of the tail motor neuron length of 24 hpf (E) and 48 hpf (F) zebrafish. For each fish, five to six neurons were measured, and the average length was calculated. Scale bar, 50 μm. The number of animals is indicated below the columns. ^*P < 0.05; ^***P < 0.001; unpaired t-test.

Expression Data

Antibodies:	Ab5-rho zpr-1
Fish:	AB wfs1a^{sa11465/sa11465} (AB) wfs1b^{sa16422/sa16422} (AB)
Anatomical Terms:	long double cone cell retinal rod cell short double cone cell
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	wfs1a^{sa11465/sa11465} (AB) wfs1b^{sa16422/sa16422} (AB)
Observed In:	long double cone cell motor neuron retinal ganglion cell retinal rod cell short double cone cell
Stage Range:	Prim-5 to Day 5

Phenotype Detail

Acknowledgments

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